USMLE Step 1 Practice Questions
Practice questions for USMLE Step 1 — biochemistry and genetics, organ-system physiology, pathology, microbiology and immunology, and pharmacology with biostatistics and medical ethics, written as short clinical-science items with explained answers. Pass to earn USMLE Step 1 Readiness SOA-USM1.
- Advanced difficulty.Assumes years in the role or deep specialist knowledge.
- 25 scenario questions
- 25 minutes, timed
- 70% to pass · 90% for distinction
- Free no sign-up needed
- LinkedIn-ready · add it to your profile in one clickSee how ↓
What is the USMLE Step 1 Practice Questions?
The USMLE Step 1 Practice Questions is a free advanced-level, 25-minute skill test from Science of Apps. Practice questions for USMLE Step 1 — biochemistry and genetics, organ-system physiology, pathology, microbiology and immunology, and pharmacology with biostatistics and medical ethics, written as short clinical-science items with explained answers. Score 70% or more on its 25 questions to earn a verifiable USMLE Step 1 Readiness certificate (SOA-USM1). Every question is based on published standards and research — including StatPearls (NCBI Bookshelf, National Library of Medicine), Anatomy and Physiology 2e (OpenStax (Rice University)) — and each answer is explained with its source.
Built for your job title
Medical student, International medical graduate, Pre-clinical student, Physician assistant student and Medical educator — and anyone who wants quick, verifiable proof of USMLE Step 1 skills for a CV or LinkedIn.
- Medical student
- International medical graduate
- Pre-clinical student
- Physician assistant student
- Medical educator
What the test covers
Five skill areas with 5 questions each, drawn from a bank of 10 per area, so a retake brings questions you haven't seen.
- 01
Biochemistry and Genetics
20%- Metabolism
- Vitamins
- Inheritance
- 02
Physiology
20%- Cardiovascular and respiratory
- Renal
- Endocrine
- 03
Pathology
20%- Cell injury
- Neoplasia
- Cardiovascular and haematologic
- 04
Microbiology and Immunology
20%- Bacteria
- Viruses
- Immune system
- 05
Pharmacology, Biostatistics and Ethics
20%- Pharmacology principles
- Biostatistics
- Ethics
Independent practice test. Science of Apps is not affiliated with, endorsed by or sponsored by the FSMB or NBME. Product and exam names are trademarks of their owners. Passing earns a Science of Apps certificate, not the official exam credential.
Based on published standards
The questions are original scenarios, and each one names the public standard, official guide or research it draws on — shown under the question while you answer, and linked in your review. These are the sources behind this test:
Try a sample question
A 4-year-old has recurrent lung infections and salty-tasting skin. The defective protein is most likely
- CFTR, a chloride channel
- fibrillin-1, a connective protein
- haemoglobin beta chain
- dystrophin, a muscle protein
Show the answer
A. CFTR, a chloride channel — Cystic fibrosis, autosomal recessive. The real test has 25 questions like this.
How the test works
25 minutes, 25 questions
One question per screen, with a progress bar and a countdown. Your progress is saved on this device if you need to pause.
Graded on our server
Answers reach the page only after you submit, so the certificate can only be earned by passing.
Every answer explained
Pass or not, you see every question with the right answer, why, and the source behind it. Pass mark 70%, distinction 90%.
Your certificate
Founder-signed, with a QR code and credential ID. Download PDF or PNG, add to LinkedIn, and it's emailed to you.
What you earn

Pass, then add it to LinkedIn in one click
No typing. The Add to LinkedIn button opens your profile’s Licenses & certifications form already filled in: the certificate name, Science of Apps as the issuer, the issue date, your credential ID and a link recruiters can use to verify it.
- 1Take the 25-minute test
- 2Score 70% or more
- 3Click Add to LinkedIn

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Frequently asked questions
What is the USMLE Step 1 Practice Questions?
The USMLE Step 1 Practice Questions is a free advanced-level, 25-minute skill test from Science of Apps. Practice questions for USMLE Step 1 — biochemistry and genetics, organ-system physiology, pathology, microbiology and immunology, and pharmacology with biostatistics and medical ethics, written as short clinical-science items with explained answers. Score 70% or more on its 25 questions to earn a verifiable USMLE Step 1 Readiness certificate (SOA-USM1). Every question is based on published standards and research — including StatPearls (NCBI Bookshelf, National Library of Medicine), Anatomy and Physiology 2e (OpenStax (Rice University)) — and each answer is explained with its source.
How do I take the USMLE Step 1 Practice Questions for free?
Read the five skill areas on this page, then take the 25-minute test online — no fee, course or sign-up. You see every answer explained when you finish. Score 70% or more and you get a USMLE Step 1 Readiness certificate straight away, on screen, as a PDF and by email, with a credential ID anyone can verify.
Are the USMLE Step 1 Practice Questions questions based on real standards?
Yes. The questions are original scenarios written by Science of Apps, and each one is based on a public source you can read: StatPearls (NCBI Bookshelf, National Library of Medicine); Anatomy and Physiology 2e (OpenStax (Rice University)). The source is shown under each question and linked in the answer review. Science of Apps doesn't copy questions from other tests.
What does the USMLE Step 1 Practice Questions cover?
Five skill areas with five questions each, drawn from a bank of 10 per area so a retake brings new questions: Biochemistry and Genetics (Metabolism, Vitamins and Inheritance); Physiology (Cardiovascular and respiratory, Renal and Endocrine); Pathology (Cell injury, Neoplasia and Cardiovascular and haematologic); Microbiology and Immunology (Bacteria, Viruses and Immune system); Pharmacology, Biostatistics and Ethics (Pharmacology principles, Biostatistics and Ethics). Every question is an original scenario based on a published standard, official documentation or research, named under the question.
Who should take the USMLE Step 1 Practice Questions?
Medical student, International medical graduate, Pre-clinical student, Physician assistant student and Medical educator. It suits anyone who wants a quick, verifiable way to show USMLE Step 1 skills, from students and career switchers to experienced professionals.
Can I use this for usmle step 1 practice test, usmle step 1 questions or step 1 review questions?
Yes. The USMLE Step 1 Practice Questions is free and covers all of these: 25 scenario questions in 25 minutes, each answer explained with the source it comes from, so it works as interview and exam practice. It isn't a full course, so use the areas you miss as your study list. Scoring 70% or more earns a verifiable certificate.
Is this the official USMLE Step 1 exam?
No. It is an independent practice test written to the publicly available USMLE Step 1 content outline, for checking your readiness before you book the real exam. Science of Apps is not affiliated with the FSMB or NBME, and passing earns a Science of Apps certificate rather than the official credential.
Can I take the USMLE Step 1 Practice Questions from any country?
Yes. The test is online, in English and free everywhere — people take it from India, the US, the UK, Europe, Africa, Latin America and Asia-Pacific. Your certificate is dated with your own local date and can be verified from anywhere at scienceofapps.com/certification/verify/.
How long is the USMLE Step 1 Practice Questions?
25 questions — 5 from each of 5 skill areas — with a 25-minute limit. You need 70% (18 of 25) to pass and 90% for distinction.
How hard is the USMLE Step 1 Practice Questions?
We rate it Advanced: assumes years in the role or deep specialist knowledge. It has 25 scenario questions — 5 from each of 5 skill areas — and a 25-minute limit. You need 70% (18 of 25) to pass and 90% for distinction.
How much do Science of Apps certifications cost?
Nothing. There is no fee to take a test, to receive the certificate, to have it emailed or to verify it, and no sign-up.
How are the tests graded?
On our server, not in your browser. The answers never reach the page until you submit, so a certificate can only be earned by passing. Each certificate gets a unique credential ID stored by Science of Apps.
What happens if I don't pass?
You see your score for each area and every question with the correct answer and why, with the published source behind it. You can retake after 30 minutes, and the retake draws questions you haven't seen yet.
Do the certificates expire?
No. Every certificate is dated, so it always shows when you passed. Retake a test any time for a newer date or a higher score.
Can I add the certificate to LinkedIn?
Yes. After you pass, Add to LinkedIn opens the Licenses & certifications form with the certificate name, Science of Apps as the issuer, the issue date, your credential ID and the verification link filled in. You can also download it as a PDF or PNG, and it's emailed to you as a PDF.
How can an employer verify my certificate?
Every certificate has a credential ID and a QR code. Scanning it, or entering the ID at scienceofapps.com/certification/verify/, shows the holder's name, the certification, the score and the issue date from our records.
Are these accredited qualifications?
No. They are Science of Apps' own assessments of applied skill. They aren't issued by a university or standards body, and they work best alongside a portfolio that shows the skills in real work.
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